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KMID : 1188320150090030340
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Gut and Liver
2015 Volume.9 No. 3 p.340 ~ p.345
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Additive Effect of Pronase on the Eradication Rate of First-Line Therapy for Helicobacter pylori Infection
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Bang Chang-Seok
Kim Yeon-Soo
Park Sang-Hyun
Kim Jin-Bong
Baik Gwang-Ho
Suk Ki-Tae
Yoon Jai-Hoon
Kim Dong-Joon
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Abstract
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Background/Aims:Helicobacter pylori colonizes on the apical surface of gastric surface mucosal cells and the surface mucous gel layer. Pronase is a premedication enzyme for endoscopy that can disrupt the gastric mucus layer. We evaluated the additive effects of pronase combined with standard triple therapy for H. pylori eradication.
Methods:This prospective, single-blinded, randomized, controlled study was conducted between June and October 2012. A total of 116 patients with H. pylori infection were enrolled in the study (n=112 patients, excluding four patients who failed to meet the inclusion criteria) and were assigned to receive either the standard triple therapy, which consists of a proton pump inhibitor with amoxicillin and clarithromycin twice a day for 7 days (PAC), or pronase (20,000 tyrosine units) combined with the standard triple therapy twice a day for 7 days (PACE).
Results:In the intention-to-treat analysis, the eradication rates of PAC versus PACE were 76.4% versus 56.1% (p=0.029). In the per-protocol analysis, the eradication rates were 87.5% versus 68.1% (p=0.027). There were no significant differences concerning adverse reactions between the two groups.
Conclusions:According to the interim analysis of the trial, pronase does not have an additive effect on the eradication of H. pylori infection (: NCT01645761).
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KEYWORD
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Helicobacter pylori, Pronase
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